Journal Article (313) Sexual Symptoms and Biologic Pathophysiologies of Post-SSRI Sexual Dysfunction: A 15 Year Review Free A Goldstein , N Kim , S Goldstein , A Drian , A Bajwa , I Goldstein The Journal of Sexual Medicine , Volume 22, Issue Supplement_4, November 2025, qdaf320.309, https://doi.org/10.1093/jsxmed/qdaf320.309 Published: 09 December 2025 Abstract Introduction Sexual side effects from a selective serotonin reuptake inhibitor (SSRI)/serotonin and norepinephrine reuptake inhibitor (SNRI) typically resolve upon discontinuation. Post-SSRI Sexual Dysfunction (PSSD) is identified in patients without history of sexual dysfunction prior to SSRI/SNRI use and, after cessation of the medication, continue to have symptoms of bothersome sexual dysfunction for ≥ 6 months, with no obvious alternative pathophysiologic risk factors. Objective To perform a retrospective chart review of men diagnosed with PSS...