Disfunzioni sessuali post-SSRI

https://rxisk.org/a-time-for-post-ssri-sexual-dysfunction/

19 Dicembre 2021, Rxisk.org Background Abbiamo notato che la mancanza di criteri diagnostici era sempre più menzionata nella letteratura pubblicata sulla disfunzione sessuale post-SSRI (PSSD). La condizione veniva descritta come difficile da diagnosticare perché non esisteva una definizione comunemente accettata. Allo stesso tempo, stavano comparendo una serie di nuovi siti web e discussioni online, molti dei quali sembravano avere interpretazioni leggermente diverse di ciò che è e non è PSSD. Anche se la condizione era già stata ben caratterizzata in letteratura, in particolare in relazione alle caratteristiche distintive della diminuzione della sensazione genitale e orgasmica, sembrava esserci la necessità di un insieme formale di criteri. Abbiamo deciso di scrivere un nuovo documento. RxISK è stato il primo gruppo a pubblicare la letteratura peer-reviewed sulla disfunzione sessuale persistente dopo l'uso di isotretinoina, un farmaco utilizzato nel trattamento dell'acne. Abbi...

Sono in corso alcune ricerche sulla sindrome da sospensione di antidepressivi da un gruppo con sede in California. Uno dei ricercatori ha cercato direttamente un gruppo di pazienti affetti da PSSD per richiedere la partecipazione. Il questionario è in inglese. La fine di questo sondaggio ti offre uno spazio per scrivere con parole tue. Partecipa se non l'hai già fatto: https://docs.google.com/forms/d/e/1FAIpQLSdbyJajhYAiVM3baJOfB5xlBVdWjbe3YduYrK-nDJwHWG-iQQ/viewform?usp=sf_link PLEASE READ THE FOLLOWING BEFORE PARTICIPATING IN THIS ONLINE SURVEY:   You are invited to take part voluntarily in an online clinical research survey. Before you decide whether to participate, please consider the following: PROJECT PURPOSE The purpose of this project is to identify the nature and severity of withdrawal symptoms occurring when stopping serotonin reuptake inhibitors (SRIs), by collecting data from individuals who have experienced SRI withdrawal. We hope that this data will inform better metr...

Australian Journal of General Practice, Volume 50, Issue 12, December 2021 Antidepressant prescribing in general practice: A call to action Katharine A Wallis     Maria Donald     Joanna Moncrieff    doi: 10.31128/AJGP-02-21-5828 The  Mental health: Productivity Commission inquiry report  (2020) recommended as a ‘priority reform’ that we ‘[a]ddress adverse outcomes from prescribing practices of mental health medication’. 1  The report states that ‘while antipsychotic prescribing in aged care facilities is one element of this … arguably a greater concern, given its frequency, is antidepressant prescribing’. 1  The report recommends that general practitioner (GP) ‘mental health training and professional development’ be improved to increase ‘adherence to evidence-based clinical practices (including the clinical appropriateness of GP’s [sic] prescribing practices for mental health medication, management of medication side effects a...

Expert Opin Drug Saf .  2021 Nov 18. PMID:  34791958   DOI:  10.1080/14740338.2022.2007883 Persistent sexual dysfunction after SSRI withdrawal: a scoping review and presentation of 86 cases from the Netherlands Katherine Chinchilla Alfaro   1 ,  Florence van Hunsel   1 ,  Corine Ekhart   1 1 Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, the Netherlands. Abstract Background:  Sexual dysfunction is highly prevalent worldwide. A specific form is persistent sexual dysfunction after SSRI withdrawal. We conducted a systematic literature review in order to characterize factors related to post SSRI sexual dysfunction (PSSD) and analyzed spontaneous reports of persistent sexual dysfunction reported to the Netherlands Pharmacovigilance Centre Lareb. Research design and methods:  A systematic literature review was conducted following the PRISMA-ScR guidelines. In addition, reports of PSSD submitted to the Netherlands Pharm...

Abstract presented in the context of: The International Society of Pharmacovigilance (ISoP) 20th ISoP Annual Meeting “Integrated pharmacovigilance for safer patients” 8–10 November 2021 Muscat, Oman https://link.springer.com/article/10.1007/s40264-021-01129-0 P060 Persistent Sexual Dysfunction in SSRI Users: Scoping Review and Presentation of 93 Cases from The Netherlands K. Chinchilla 1 , F. van Hunsel 1 ,  C. Ekhart   1 1 Netherlands Pharmacovigilance Centre Lareb, Signal Detection, ‘s-Hertogenbosch, The Netherlands Background/Introduction:  SSRIs are potent disruptors of sexual function. These effects can persist after the discontinuation of the SSRI, leading to Post SSRI Persistent Sexual Dysfunction (PSSD). This refers to a hypodynamic sexual state that can persist for decades carrying a high impact on the patient’s life (1, 2). Objective/Aim:  To map the characteristic factors related to PSSD through a literature review, and present the...