Disfunzioni sessuali post-SSRI

Molecular Neurobiology   https://doi.org/10.1007/s12035-024-04592-9 Transcriptomic Profile of the Male Rat Hypothalamus and Nucleus Accumbens After Paroxetine Treatment and Withdrawal: Possible Causes of Sexual Dysfunction Published: 04 November 2024 Silvia Giatti, Lucia Cioffi, Silvia Diviccaro, Gabriela Chrostek, Rocco Piazza & Roberto Cosimo Melcangi Abstract Paroxetine, a selective serotonin reuptake inhibitor (SSRI), may induce sexual dysfunction during treatment and upon discontinuation. The mechanisms involved have been poorly explored so far. We have analyzed, by RNA sequencing, the whole transcriptomic profile in the hypothalamus and nucleus accumbens (NAc) (two brain regions involved in sexual behavior) of male rats daily treated for 2 weeks with paroxetine (T0) and at 1 month of withdrawal (T1). Data here reported show seven differentially expressed genes (DEGs) at T0 and 1 at T1 in the hypothalamus and 245 at T0 and 6 at T1 in the NAc. In addition, Gene-Set Enrichment,

Acta Psychiatr Scand. 2024 Oct 3. doi: 10.1111/acps.13764. Not all types of depressed patients who persist with their antidepressant treatment improve in side effect complaints: A comparison of treatment completers and dropouts in the STAR*D trial Thomas T Kim   1 ,  Colin Xu   2 Affiliations 1 Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA. 2 Department of Psychology & Communication, University of Idaho, Moscow, Idaho, USA. PMID:  39363550   DOI:  10.1111/acps.13764 Abstract Introduction:  There is a "traditional belief" that antidepressant side effect complaints improve with medication persistence; however, support for this theory has remained inconclusive. We aimed to examine if side effect complaints improved over time by modeling the relationship between side effect complaints and time at dropout for patients receiving citalopram during the first level of acute treatment in the Sequenced Treatment Alternatives to Relieve Depression