The serotonin theory of depression: a systematic umbrella review of the evidence (2022)
Systematic Review Open Access Published: 20 July 2022 The serotonin theory of depression: a systematic umbrella review of the evidence Joanna Moncrieff , Ruth E. Cooper , Tom Stockmann , Simone Amendola , Michael P. Hengartner & Mark A. Horowitz Molecular Psychiatry ( 2022 ) Abstract The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception until December 2020. Systematic reviews, meta-analyses and large data-set analyses in the following areas were identified: serotonin and serotonin metabolite, 5-HIAA, concentrations in body fluids; serotonin 5-HT 1A receptor binding; serotonin transporter (SERT) levels...